Combating disease with cryptic metabolites
The Cryptyx Bioscience drug discovery platform provides a rapid, efficient approach for activating silent biosynthetic gene clusters and unearthing potential leads that cannot be accessed with extant technologies.
We develop novel disease therapies
Many clinically used antibiotics and other medicines are derived from bacterial small molecules produced by dedicated biosynthetic gene clusters (BGCs). Recent investigations, however, have shown that these are the tip of the iceberg and that the majority of BGCs encoded in microbial genomes are transcriptionally silent or "cryptic." Identifying the triggers that lead to activation of these silent clusters has the potential to greatly expand our repertoire of therapeutic molecules.
Unlike nearly all existing methods developed to activate silent BGCs, our platform does not require complex genetic, cloning, or culturing procedures, can be used with both sequenced and unsequenced bacteria, and reliably reports on the bioactivity of the cryptic metabolite. We are currently using our technology platform to advance novel therapies for bacterial and viral pathogens and are in the process of expanding our R&D to oncology.
Leverage our platform
We offer several ways for clients to work with us and our platform to bring cryptic metabolite drug leads to market.
Drug leads licensing
We have IP around hundreds of novel metabolites with a broad range of biological activities. We make these microbially produced, bacterial small molecules available for out-licensing purposes.
Cryptyx-developed drug leads
We develop drug leads toward clinical trials. Our discovery platform can be adapted to any drug target and we are currently tackling several disease areas including bacterial and viral pathogens and oncology.
Metabolite library purchase
Biochemical researchers and other experts who are interested in employing our novel metabolites in their work may purchase our metabolite library for use in any desired screening assay.
A genetics-free method for high-throughput discovery of cryptic microbial metabolites.
Fei Xu, Yihan Wu, Chen Zhang, Katherine M. Davis, Kyuho Moon, Leah B. Bushin, and Mohammad R. Seyedsayamdost
High-throughput platform for the discovery of elicitors of silent bacterial gene clusters.
Mohammad R. Seyedsayamdost